Sweet 16 – Arizona vs. Duke Betting Pick & Prediction – Thursday, March 27, 2025

The fourth-seed Arizona Wildcats (24-12) and top-seed Duke Blue Devils (33-3) will square off in the Sweet 16 of the East Region when their battle begins on Thursday, March 27 at 9:39 PM ET at the Prudential Center in Newark, New Jersey. MyBookie has the Blue Devils as favored with a point spread at -8.5 (-115).

Arizona Wildcats Betting Preview

The Wildcats have won their last two games and are 4-1 overall in their last five. Their most recent victory was an 87-83 performance over the fifth-seed Oregon Ducks in the Second Round of the tournament.

Arizona bounced back from an early double-digit deficit and actually took the lead at the half (42-38). Both teams would score 45 points in the second, with the Wildcats making big plays down the stretch to keep the lead. Caleb Love led with 29 points and four assists.

Oregon connected on 47.1 percent of their shots from the field and made 35.0 percent of their threes. The Wildcats made 45.5 of their shots overall and made half of their threes. Free throws were also big, as the Wildcats were 70.8 percent while the Ducks were 54.5 percent from the line.

The Wildcats have been averaging 90.0 points and allowing 74.0 so far this tournament. Overall this season, they have put up 82.2 points a game and have given up 72.5, which ranks 18th and 200th, respectively.

Duke Blue Devils Betting Preview

The Blue Devils have now put up 13 consecutive wins and are one of the favorites to win the tournament. They are coming off a man 89-66 blowout over the Baylor Bears in the Second Round.

Duke already had a double-digit lead by halftime and was able to keep that momentum alive in the second. Tyrese Proctor led with 25 points and only missed one bucket out his 10 attempts.

Baylor was smothered and only made 36.8 percent of their field goals and 32.0 percent of their threes. Duke was able to play comfortably with making 64.4 percent of their shots and 54.5 percent of their long range shots.

The Blue Devils rank 12th in scoring at 83.2 points a game and rank sixth for allowing 61.7 points to opponents. For these first two games they have put up 91 points and have allowed 57.5 points from opponents.

Odds, Series Trends, and Free Pick

MyBookie showcases the best Arizona Wildcats vs. Duke Blue Devils betting odds with the Blue Devils cast as 8.5-point favorites. The Blue Devils have a 76.0 percent chance of winning according to market predictions.

The spread is more appealing since it first opened at 9.5. Look for Duke to cover the spread and move onto the next round.

Final Pick: Duke Blue Devils -8.5 (-115)