Sweet 16 – Ole Miss vs. Michigan St Expert Pick & Prediction – March 28, 2025

Another Sweet 16 battle that you cannot miss will be between the sixth-seed Ole Miss Rebels (24-11) and second-seed Michigan State Spartans (29-6) on Friday, March 28th at 7:09 PM ET at the State Farm Arena in Atlanta, Georgia. MyBookie offers the Spartans as slight favorites with a point spread at -3.5 (-115).

Ole Miss Rebels Betting Preview

The Rebels have had two impressive victories to start this tournament run. Their most recent one was a 91-78 performance over the Iowa State Cyclones in the Second Round. Their first matchup was a 71-64 win over the North Carolina Tar Heels, where they had a 20-point lead at one point.

Ole Miss came out swinging in the first half with a 40-29 performance, which carried over into the second. Sean Pedulla was excellent, as he led with 20 points and eight assists (with only one turnover, too). If Pedulla can drive the offense like this and get teammates involved, they are unstoppable in the half court setting.

Iowa State shot 48.2 percent from the field and made 36.4 percent of their shots from deep. While that is pretty good, the Rebels did even better with 58.2 percent from the field and 57.9 (11-19) from long range. This hot shooting and great ball movement propelled them to victory.

The Rebels have put forth 77.4 points each matchup while giving up 71.7 from opponents. Their current tournament run has been 81.0 points on offense and 71.0 points allowed. This is a solid spread, assuming they continue to perform well on both ends of the floor.

Michigan State Spartans Betting Preview

The Spartans have won four out of their last five games and are currently on a two-game win streak. Their previous encounter was a 71-63 win over the 10th-seed New Mexico Lobos.

Michigan State was down by two at the half but was able to bounce back quickly in the second with a stronger push on offense. Jaden Akins led with 16 points on 63.6 percent shooting on the floor.

New Mexico made 48.2 percent of their buckets and 30.8 percent of their three pointers. Michigan State made roughly the same amount of shots but did not look as appealing on paper with 44.4 percent accuracy overall from the field and 26.7 percent from deep.

The Spartans’ offense has put up 78.2 points a game this season while their defense has allowed 67.0 points. Their tournament averages so far have been 79.0 points scored and 62.5 points a game allowed.

Odds, Series Trends, and Free Pick

MyBookie has provided you with the best Ole Miss Rebels vs. Michigan State Spartans betting odds, showing the Spartans as 3.5-point favorites. According to market data, the Spartans have a 64.5 percent chance to win. The Spartans are the better team when looking at efficiency on both ends of the floor, so look for them to cover the spread.

Final Pick: Michigan State Spartans -3.5 (-115)