San Diego Padres vs. San Francisco Giants Betting Preview (June 2, 2025)

First Pitch: 9:45 p.m. ET | Oracle Park, San Francisco

Tonight marks the start of a crucial four-game showdown between the San Diego Padres and San Francisco Giants at Oracle Park, with the first pitch slated for 9:45 p.m. ET. The NL West standings are tight San Diego comes in at 33–24, with the Giants hot on their heels at 33–26. Every game in this series could shift the division picture.

The Padres are handing the ball to right-hander Stephen Kolek (3–1, 4.11 ERA), who’s quietly been a force on the road – he’s 2–0 with a stellar 1.33 ERA in three starts away from Petco Park. The Giants counter with their ace, Logan Webb (5–5, 2.82 ERA), who’s been even sharper at home, posting a 3–1 record and a dominant 1.39 ERA over five Oracle Park starts.

The last time these two met back on April 30 – the Padres took the upper hand with a 5–3 win to complete a brief two-game sweep. Elias Díaz went yard and scored twice, while Fernando Tatis Jr. tallied three hits in a strong leadoff showing.

As for the betting line? The Giants are favored -178 at Bookmaker, with the Padres listed as +149 underdogs at SportsBetting.ag. The total sits at 7.5 runs, reflecting the strong pitching matchup on tap. With both clubs jostling for position in the division, tonight’s opener should be anything but predictable.

Pitching Matchup: Webb vs. Kolek

Logan Webb (SF):

Record: 5–5 | ERA: 2.82 | WHIP: 1.21 | K: 84
Webb has been an anchor in the Giants’ rotation, and his dominance at home is hard to overlook: 3–1 with a 1.39 ERA in five Oracle Park starts. He’s also quietly evolved into one of MLB’s best at neutralizing the running game – no steals allowed against him all year.

Stephen Kolek (SD):

Record: 3–1 | ERA: 4.11 | WHIP: 1.30 | K: 24
Kolek has been surprisingly solid since moving into the starting role. On the road, he’s been outstanding, posting a 1.33 ERA in three starts. His pitch-to-contact approach has worked well, though his high hard-hit percentage and modest strikeout rate could be red flags against better lineups.

Recent Form & Betting Trends

San Diego Padres:

5–2 in their last 7 games
5–0 in their last 5 vs. the Giants
2–5 in their last 7 on the road
The UNDER has hit in 8 of their last 9 road games against San Francisco

San Francisco Giants:

2–4 in their last 6 games
The UNDER has cashed in 9 straight games
Closed their road trip with a strong 4–2 win in Miami

Betting Market Breakdown

Moneyline: Giants -178 | Padres +149
Run Line: Giants -1.5 (+121) | Padres +1.5 (-145)
Over/Under: 7.5 runs (Over -102, Under -123)

The odds favor San Francisco, mostly due to Logan Webb’s presence and their return to home turf. Still, the Padres have played them well this year and could offer value as underdogs—if Kolek continues to outpitch his peripherals.

Expert Prediction and Best Bet

Final Score Prediction: Giants 4, Padres 3

Logan Webb’s consistency and Oracle Park dominance should give the Giants the edge in this matchup, especially against a Padres lineup that has been inconsistent on the road. Kolek’s strong road numbers can’t be ignored, but the Giants’ bullpen depth and recent offensive momentum give them just enough to squeak this one out.

💰 Free MLB Pick: UNDER 7.5 runs (-123)
Both teams are trending toward low-scoring games, and with two pitchers performing well in their current roles, expect a pitchers’ duel in the Bay. The under has been money—literally—in recent Giants and Padres games.