NFL Betting Preview: Tennessee Titans vs. San Francisco 49ers – Thursday, December 23, 2021

by Spooky Express | December 20, 2021 |

Week 15 still has a number of games to close after the delays from the health and safety protocols across the NFL, but we are already looking ahead to the next edition of Thursday Night Football. A team that is as hot as anyone in the league right now, the San Francisco 49ers will be on the road to take on the Tennessee Titans in a cross-conference matchup for Week 16.

At the time of this article being published, there are quite literally four more games to be played to wrap up Week 15.  Once those conclude, we will have a better understanding of the playoff picture and where both of these teams for the Thursday night matchup will be finding themselves in the standings.

This game has extremely important playoff implications, so let’s break down the matchup and help you determine your best bets.

San Francisco 49ers Betting Preview: A dominant rushing attack from San Fran

If one thing is for certain in the NFC and in the NFL, it is that the 49ers are going to win games on the back of their rushing attack, regardless of who is on the field. They have lost a number of backs on the season due to injuries and COVID, and their most recent outing saw Jeff Wilson Jr. dominate along with another stellar performance from Deebo Samuel.

Samuel is the X-factor for this entire offense, as he has transformed them into one of the best in the league with his elevated play this season. It has made the job of Jimmy Garoppolo much easier game to game. As long as he can avoid turning the ball over, the 49ers should be in a good position moving forward.

Tennessee Titans Betting Preview: A mess towards the top of the AFC

The Titans have had the luxury of resting towards the top of the AFC for much of this season thanks to the below average division they are in. Their team's build since Derrick Henry’s injury has been head-scratching. It has been a consistent struggle to keep any of their top receivers healthy.

This has only made Ryan Tannehill’s job at quarterback harder. They welcomed Julio Jones back into the mix, only for him to exit their game against Pittsburgh with another hamstring injury. Who knows how relevant the Titans will be to end the year, but they have as good a chance as any to win this game at home.

49ers @ Titans Betting Odds and Lines

Coming into Week 16’s edition of Thursday Night Football, the people over at MyBookie have the San Francisco 49ers favored on the road over the Tennessee Titans by two points. 

With how hot the 49ers have been, they get the nod even on the road in this game against the Titans.

Free Betting Pick

There were too many turnovers for the Titans against the Steelers, and the 49ers defense should have no trouble creating the same amount of pressure and confusion.

Roll with San Francisco for this game and expect a big one from Deebo Samuel.

Spooky Express Free Betting Pick: San Francisco 49ers @ -2

Spooky Express is your NFL Football headquarters with game breakdowns, betting analysis, free plays, sportsbook bonus offers, and more!  

Share This
GET YOUR $150 BONUS AT US RACING Open your US Racing account to claim your $150 bonus with Promo Code SPOOKY. Click Here to Claim Your Bonus with Promo Code SPOOKY
New call-to-action