NFL Preview: San Francisco 49ers vs. Buffalo Bills – Sunday, Dec. 1, 2024

The San Francisco 49ers (5-6) are aiming to get back on track when they face the Buffalo Bills (9-2) on Sunday, December 1 at 8:20 PM ET at Highmark Stadium in Orchard Park, New York. The Bills are favored at home with a point spread at -7.0 (-105).

San Francisco 49ers Betting Preview

The 49ers are currently on a two-game skid heading into this matchup and are likely still without Brock Purdy under center. Their latest defeat was a 38-10 blowout against the Green Bay Packers.

Brandon Allen had 199 yards, a touchdown, and an interception on 17 of 29 completions. Purdy is listed as questionable, but earlier in the week he was not named the starter, so most likely you will not see him.

They had a terrible game offensively with three turnovers, 11 first downs, and just 241 yards total. Their defense was even worse, as they allowed 325 yards and 22 downs, without forcing a single turnover. On top of that, they allowed the Packers to have the ball in their hands for nearly 37 minutes.

The 49ers are 13th in the league when looking at points per game, which is at 23.6. Defensively they rank 20th in allowing opponents to put up 23.6 as well. This does not get them anywhere if they are breaking even on paper.

Buffalo Bills Betting Preview

The Bills are riding a six-game win streak and have excellent momentum approaching this game. Their recent success was a 30-21 outing over the Kansas City Chiefs, which ended the Chiefs run at a perfect season (previously 9-0).

Josh Allen clinched the game with a 26-yard touchdown run in the final two minutes of the game. He completed 27 of 40 passes for 262 yards and a touchdown, but also threw an interception.

Offensively they amassed 366 yards and 24 first downs while having possession for 34 minutes of action. On defense they held the Chiefs to 259 yards and 19 first downs while also forcing two costly turnovers.

The Bills are third in the league in scoring with 29.1 points per game. Their defense has been appealing in holding teams to 19.5 points per game, ranking seventh. This is a great spread, showing their margin of error has been consistent.

Odds, Series Trends, and Free Pick

The NFL betting odds from MyBookie are appealing in the upcoming San Francisco 49ers vs. Buffalo Bills battle, which currently shows the Bills as seven-point favorites. Market analysis gives the Bills a 61.3 percent chance at winning outright.

The 49ers were short handed in their last matchup and they appear to be the same this time around. Without Purdy, their offense suffers. Look for the Bills to win and cover the spread.

Final Pick: Buffalo Bills -7.0 (-105)