NFL Thursday Night Football Preview: Los Angeles Rams vs. San Francisco 49ers – Thursday, Dec. 12, 2024

Check out the upcoming Thursday Night Football action between the Los Angeles Rams (7-6) and San Francisco 49ers (6-7), on December 12 at 8:15 PM ET. This NFL betting opportunity will be at Levi’s Stadium in Santa Clara, California, with current odds showing the 49ers favored with a point spread at -2.5 (-115).

Los Angeles Rams Betting Preview

The Rams have won their last two games and are now above .500 on the season. Their most recent success was a 44-42 performance over the Buffalo Bills.

They had a 38-21 lead heading into the fourth quarter, but then gave up 21 points in the fourth and almost lost their lead. Matthew Stafford had a great game, boasting 23 of 30 completions totaling 320 yards and two touchdowns.

This was a close game overall when looking at the stats, as both teams had comparable yards, first downs, and no turnovers. However, the Rams had possession of the ball for 38.5 minutes of action that ultimately gave them the edge they needed to hold off a run by the Bills.

The Rams’ offense ranks 16th in the league for averaging 22.9 points a game. On defense they rank 24th in giving up 25.5 points to their opponents per game, which shows a slightly negative correlation. They will need to gather a good lead early again to put themselves in a position to win.

San Francisco 49ers Betting Preview

The 49ers ended their three game losing skid with a 38-13 blowout over the Chicago Bears last Sunday. With a 24-0 lead at the half, they looked like the team that made it to the Super Bowl a year prior.

Brock Purdy was back to his former self, as he completed 20 of 25 passes for 325 yards and two touchdowns. Isaac Guerendo led the ground game with 15 carries that totaled 78 yards and two touchdowns.

They established 452 yards and 22 first downs, all while holding the Bears to 162 yards and 14 first downs. Each team committed one turnover, but that did not make the biggest impact as the total conversions in the endzone.

The 49ers are 11th in the league for averaging 23.7 points a game. Their defense comes in at 21st, as they have been allowing their opposition to get 23.7 points on them as well. As you can see, this shows they could break even each game or at least be coin flip for the win.

Odds, Series Trends, and Free Pick

MyBookie has the best Thursday Night Football odds for the Los Angeles Rams vs. San Francisco 49ers matchup, which favors the 49ers by 2.5-points. Current matchup predictions indicate the 49ers have a 60.8 percent chance at winning overall.

The Rams are appealing with their win streak and look revived. The 49ers have a great shot as well, but they took advantage of a weaker Bears’ team last week to give them a boost.

Final Pick: Los Angeles Rams +2.5 (-105)