Eintracht Frankfurt vs Liverpool: Champions League Pick & Prediction – October 22, 2025
Two out-of-form sides resume their Champions League campaigns on Wednesday night, as Eintracht Frankfurt and Liverpool face off at Deutsche Bank Park in a clash that could prove pivotal for both teams.
Both clubs enter Wednesday’s game under pressure after recent setbacks. The Bundesliga side were humbled 5–1 by Atletico Madrid on Matchday 2 of the Champions League, while Liverpool’s 1-0 loss at the hands of Galatasaray left them equally desperate for a response.
For Arne Slot’s side, who also suffered a painful 2-1 defeat to Manchester United on Sunday – their first home loss to their arch-rivals in nearly a decade – this fixture offers both danger and opportunity.
Head-to-Head History (H2H: Eintracht Frankfurt vs Liverpool)
These two clubs have rarely crossed paths in competitive football. Their only previous meetings date back over half a century to the 1972–73 UEFA Cup, where Liverpool earned a 2–0 win at Anfield before playing out a 0–0 draw in Frankfurt. The Reds went on to win the tournament that year, setting the tone for their golden era in Europe.
Liverpool boast a generally positive record against German opposition, winning 26 of their 48 encounters while losing just seven.
Eintracht Frankfurt: Current Form and Team News
After their highest Bundesliga finish (3rd) in over three decades last season, Eintracht Frankfurt have found the going much tougher this time around. Dino Toppmöller’s men are currently seventh in the Bundesliga standings with 10 points from seven matches – three fewer than at the same stage last term.
Their defensive record is deeply concerning. Frankfurt have conceded 18 goals in their last five matches across all competitions, letting in at least twice in six of their previous seven. The recent 5-1 thrashing by Atletico Madrid only underlined how quickly their shape disintegrates under sustained pressure.
However, the Eagles remain dangerous in attack. They have scored 17 goals across their last six games, with only one of their last 67 European outings finishing goalless – a staggering record that points to their end-to-end style.
Still-teenage sensation Can Uzun, who will celebrate his 20th birthday soon, remains one of Frankfurt’s brightest talents and joint top scorer with six goals. The Turkey international is expected to operate just behind striker Jonathan Burkardt, while Ellyes Skhiri and Hugo Larsson will anchor the midfield.
Elsewhere, Robin Koch and Arthur Theate are set to retain their places at centre-back, despite recent criticism over their performances.
Liverpool: Current Form and Team News
It’s been a sobering few weeks for Arne Slot’s Liverpool, whose early-season promise has faded into a worrying slump. Sunday’s 2-1 defeat to Manchester United marked their fourth consecutive loss in all competitions – the club’s worst run since November 2014.
Liverpool’s defensive issues have been particularly costly. The Reds have conceded 16 goals in 11 matches this season, compared to just 15 across their first 22 fixtures of the previous campaign. Slot’s high-possession, aggressive pressing approach has often left full-backs (mostly Milos Kerkez and Conor Bradley) overexposed, while their transition defense remains alarmingly porous.
Going forward, Arne Slot’s Reds have scored only three goals in their last four games, and their once-cohesive front line looks short of confidence right now. Liverpool’s European pedigree remains strong, though. The Merseysiders have won 19 of their last 22 Champions League group or league phase matches – but both recent defeats (to PSV Eindhoven and Galatasaray) have come away from Anfield, adding to the pressure on this midweek trip.
Injuries continue to complicate matters for Slot. Ryan Gravenberch is almost certain to miss the trip to Frankfurt after sitting out Tuesday’s open training session due to an ankle problem sustained against Manchester United. His absence is a fresh blow in an already disjointed midfield.
Furthermore, goalkeeper Alisson Becker as well as youngsters Giovanni Leoni and Stefan Bajcetic are all long-term absentees.
There is, however, some positive news. Wataru Endo returned to full training after overcoming a hamstring issue that sidelined him for the United clash and Japan’s recent international fixtures. Meanwhile, Alexis Mac Allister was also involved in training despite receiving four stitches to a head wound on Sunday. Both midfielders, along with Curtis Jones, are potential candidates to replace Gravenberch as the holding midfielder in Germany.
Elsewhere, Andrew Robertson is expected to start at left-back in place of Kerkez, while Joe Gomez could come in for Ibrahima Konate in defense. Up front, Hugo Ekitike should lead the line against his former club, ahead of Alexander Isak, who is struggling to adapt to his new surroundings
Tactical Duel: Toppmöller vs Slot
Dino Toppmöller prefers an expansive 4-2-3-1 setup, encouraging quick vertical transitions through Bahoya, Uzun and Doan. While this system can overwhelm weaker opponents, it has left the Eagles dangerously open between the lines. The double pivot of Skhiri and Larsson has struggled to protect the back four, especially against sides pressing with intensity.
Arne Slot, meanwhile, continues to insist on high pressing and structured possession, but Liverpool’s execution has faltered badly. The loss of compactness in midfield and uncertain defensive coverage – particularly on transitions – have been key factors in their recent slump. Expect Liverpool to dominate the ball, with Salah and Wirtz tasked to exploit spaces behind Frankfurt’s adventurous full-backs.
All in all, both sides thrive in chaotic, open games – which makes another goal-heavy contest entirely plausible in Frankfurt.
Possible Starting Lineups of Eintracht Frankfurt and Liverpool
Eintracht Frankfurt: Kaua Santos – Rasmus Kristensen, Robin Koch, Arthur Theate, Nathaniel Brown – Hugo Larsson, Ellyes Skhiri – Ritsu Doan, Can Uzun, Jean-Mattéo Bahoya – Jonathan Burkardt. (4-2-3-1)
Liverpool: Giorgi Mamardashvili – Jeremie Frimpong, Joe Gomez, Virgil van Dijk, Andy Robertson – Curtis Jones, Alexis Mac Allister – Mohamed Salah, Florian Wirtz, Cody Gakpo – Hugo Ekitike. (4-2-3-1)
Eintracht Frankfurt vs Liverpool Betting Odds and Prediction
With only one of Frankfurt’s last 67 European games ending scoreless, history suggests that Wednesday’s meeting is unlikely to be short on goalmouth action. According to the latest betting odds from EveryGame, Liverpool are -175 favorites, with Eintracht Frankfurt at +400 and the draw priced at +360.
Given both sides’ leaky defenses and attacking intent, this clash has all the ingredients for a high-scoring encounter. Eintracht Frankfurt rarely play dull games – 11 of their last 12 have produced over 3.5 goals.
While the Reds look in a better position to eventually stop their losing streak, their defensive instability makes a clean sheet unlikely. Eintracht Frankfurt’s energy at home could keep the contest alive throughout, but the Reds’ superior quality in the final third should see them edge this one.
Liverpool’s Champions League experience should help them weather the storm, but expect another unpredictable, end-to-end affair.